[Medlife]A 484954|142557-61-7
简介:A-484954 是真核延长因子 2 (eEF2) 的高度选择性抑制剂,其 IC50 值为 280 nM。
物理化学性质:
密度 | 1.522±0.06 g/cm3 (20 ºC 760 Torr) |
---|---|
分子式 | C13H15N5O3 |
分子量 | 289.29000 |
精确质量 | 289.11700 |
PSA | 127.72000 |
LogP | 0.40840 |
外观性状 | white to beige |
储存条件 | 2-8°C |
水溶解性 | DMSO: soluble 3mg/mL, clear (warmed) |
详细介绍:
中文名称: | 7-氨基-1-环丙基-3-乙基-2,4-二氧代吡啶并[2,3-d]嘧啶-6-羧酰胺 |
中文别名: | 7-氨基-1-环丙基-3-乙基-1,2,3,4-四氢-2,4-二氧代-吡啶并[2,3-D]嘧啶-6-甲酰胺;7-氨基-1-环丙基-3-乙基-2,4-二酮代吡啶并[2,3-d]嘧啶-6-甲酰胺;7-氨基-1-环丙基-3-乙基-2,4-二氧代吡啶并[2,3-d]嘧啶-6-羧酰胺 |
英文名称: | Pyrido[2,3-d]pyrimidine-6-carboxamide,7-amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxo- |
英文别名: | Pyrido[2,3-d]pyrimidine-6-carboxamide, 7-amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxo-;7-Amino-1-cyclopropyl-3-ethyl-2,4-dioxopyrido[2,3-d]pyrimidine-6-carboxamide;7-Amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide;A 484954;A-484954;Pyrido[2,3-d]pyrimidine-6-carboxamide,7-amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dio...;Pyrido[2,3-d]pyrimidine-6-carboxamide,7-amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxo-;7-AMino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyriMidine-6-carboxaMide;Kinome_3822;X5939;7-Amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxo-pyrido[2,3-d]pyrimidine-6-carboxamideddd |
CAS号: | 142557-61-7 |
分子式: | C13N5O3H15 |
分子量: | 289.29 |
详细描述 | Medlife,致力于提供高品质、高性价比小分子化合物的产品。Medlife小分子化合物大量库存,提供超过2万种的抑制剂、激动剂、拮抗剂等产品,是药物及疾病研究的重要原料供应商。真核延伸因子-2(eEF-2)激酶抑制剂,A-484954 是真核延长因子 2 (eEF2) 的高度选择性抑制剂,其 IC50 值为 280 nM。 |
参考文献:
[1]. Chen Z, et al. 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J Biol Chem. 2011 Dec 23;286(51):43951-8.
[2]. Kodama T, et al. Mechanisms underlying the relaxation by A484954, a eukaryotic elongation factor 2 kinase inhibitor, in rat isolated mesenteric artery. J Pharmacol Sci. 2018 May;137(1):86-92.
[3]. Kameshima S, et al. Eukaryotic elongation factor 2 kinase mediates monocrotaline-induced pulmonary arterial hypertension via reactive oxygen species-dependent vascular remodeling. Am J Physiol Heart Circ Physiol. 2015 May 15;308(10):H1298-305.
Medlife品牌是国内知名的小分子化合物品牌,致力于信号通路、抑制剂、激动剂等产品的研发及产品供应服务,同时还可提供重组蛋白、植提、寡核苷酸等系列的产品。
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