中文名称 ：L-NAME hydrochloride.

中文别名：N'-硝基-L-精氨酸甲酯盐酸盐;N-硝基-L-精氨酸甲酯;N(ω)-硝基-L-精氨酸甲酯盐酸盐;N-硝基-L-精氨酸甲酯盐酸盐;NG-硝基-L-精氨酸甲基酯盐酸盐;NG-硝基-L-精氨酸甲酯盐酸盐;Nomega-Nitro-L-arginine Methyl Ester Hydrochloride N(ω)-硝基-L-精氨酸甲酯盐酸盐;Nω-硝基-L-精氨酸甲酯盐酸盐;N-硝基-L-精氨酸甲基酯盐酸盐;N''-硝基-L-精氨酸甲酯盐酸盐;一氧化氮合酶抑制剂;N’-硝基-L-精氨酸甲酯盐酸盐;精氨酸硝基盐酸盐

英文名称：Methyl N5-(imino(nitroamino)methyl)-L-ornithine monohydrochloride

英文别名：(S)-Methyl 2-amino-5-(3-nitroguanidino)pentanoate hydrochloride;H-Arg(NOZ)-OMe.HCl;L-NAME hydrochloride;N'-Nitro-L-arginine methyl ester hydrochloride;Nomega-Nitro-L-arginine Methyl Ester Hydrochloride;L-NAME;(S)-Methyl 2-amino-5-(3-nitroguanidino)-pentanoate hydrochloride;H-Arg(NO?)-OMe·HCl;H-Arg(NO₂)-OMe · HCl;H-Arg(NO2)-OMe.HCl;H-Arg(NO2)-OMe·HCl;H-Arg(NO2)-OMe·HClN-ω-Nitro-L-arginine methyl ester hydrochloride;H-Arg(NO2)-OMe•HCl;L-NAME (hydrochloride);L-NAME,BR;methyl (2S)-2-amino-5-[[amino(nitramido)methylidene]amino]pentanoate,hydrochloride;NG-Nitroarginine methyl ester hydrochloride;Nitroarginine Methyl;Nitroarginine Methyl Ester Hydrochloride;N'-Nitro-L-arginine-methyl ester hydrochloride;N-ω-Nitro-L-arginine methyl ester hydrochloride;Nω-Nitro-L-arginine methyl ester hydrochloride;NG-Nitro-L-arginine-methyl ester hydrochloride;LNAME hydrochloride;L-NAME HCl;NG-Nitro-L-arginine methyl ester hydrochloride;L-NAME, HCl;L-NAME HCl;NG-NO2-L-Arg-OMe;H-Arg(NO)-OMe HCl;Nomega-NO2-L-Arg-OMe;Methyl N5-(imino(nitroamino)methyl)-L-ornithine monohydrochloride;H-Arg(NO2)-OMeHCl;methyl (2S)-2-amino-5-(3-

Cas No.：51298-62-5

分子式：C7H16ClN5O4

分子量：269.69

包装储存：

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (

生物活性 ：L-NAME hydrochloride inhibits NOS with an IC50 of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC50 value of 1.4 μM.

性状：Solid

IC50 & Target[1][2]

IC50: 70 μM (NOS)

体外研究(In Vitro)：

L-arginine analogues are widely used inhibitors of nitric oxide synthase (NOS) activity, with N-nitro-L-arginine methyl ester (L-NAME) being at the head. Freshly dissolved L-NAME is a 50 fold less potent inhibitor of purified brain NOS (mean IC50= 70 μM) than L-NOARG (IC50= 1.4 μM), but the apparent inhibitory potency of L-NAME approached that of L-NOARG upon prolonged incubation at neutral or alkaline pH. HPLC analyses reveal that NOS inhibition by L-NAME closely correlated with hydrolysis of the drug to L-NOARG.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)：

L-NAME infusion significantly decreases NKT-leukocyte level, tumor-necrosis factor (TNF)-alpha production by T-splenocytes and macrophages, and IFNγ production by T-leukocytes, monocytes, and T-splenocytes, as well as increased interleukin-6 production by T-leukocytes and monocytes and nitrate/nitrite production by T-leukocytes. There is increasing evidence that nitric oxide may be involved in learning and memory. l-NAME produces a task-dependent impairment of fear extinction, and implies that nitric oxide signaling is involved in memory process of certain fear extinction tasks. Chronic L-NAME administration induces cardiac hypertrophy in rodent models. Six weeks L-NAME administration induces significant cardiac hypertrophy compared to control hearts.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件：Room temperature or refrigerated transportation.

储存方式：

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献：

[1]. Pfeiffer S, et al. Inhibition of nitric oxide synthesis by NG-nitro-L-arginine methyl ester (L-NAME): requirement forbioactivation to the free acid, NG-nitro-L-arginine. Br J Pharmacol. 1996 Jul;118(6):1433-40. [Information]

[2]. Kopincová J, et al. L-NAME in the cardiovascular system - nitric oxide synthase activator? Pharmacol Rep. 2012;64(3):511-20. [Information]

[3]. Lo HC, et al. The Nitric Oxide Synthase Inhibitor NG-Nitro-L-Arginine Methyl Ester Diminishes the Immunomodulatory Effects of Parental Arginine in Rats with Subacute Peritonitis. PLoSOne. 2016 Mar 23;11(3):e0151973. [Information]

[4]. Luo H, et al. Effect of nitric oxide synthase inhibitor L-NAME on fear extinction in rats: a task-dependent effect. Neurosci Lett. 2014 Jun 20;572:13-8. [Information]

[5]. Ocsan RJ, et al. Chronic NG-nitro-l-arginine methyl ester (L-NAME) administration in C57BL/6J mice induces a sustained decrease in c-kit positive cells during development of cardiac hypertrophy. J Physiol Pharmacol. 2013 Dec;64(6):727-36. [Information]

sealed storage, away from moisture)

研究方向

1. 一氧化氮合酶（NOS）抑制研究：

L-NAME hydrochloride作为NOS的抑制剂，被广泛用于研究NOS在生物体内的功能及其与相关疾病的关系。通过抑制NOS的活性，科学家可以观察一氧化氮（NO）生成减少后生物体的生理和病理变化。

2. 心脑血管疾病模型构建：

L-NAME hydrochloride是一种经典的高血压建模剂。通过给予动物（如大鼠、小鼠）L-NAME hydrochloride，可以减少动物体内NO的释放，从而诱导高血压等心脑血管疾病模型。这些模型对于研究心脑血管疾病的发病机制、药物治疗以及预防策略具有重要意义。

3. 药物相互作用与药效学研究：

L-NAME hydrochloride还被用于研究与其他药物的相互作用以及药效学特性。例如，在联合用药的情况下，观察L-NAME hydrochloride对其他药物疗效的影响，以及药物代谢和排泄的变化等。

研究目标

1. 阐明NOS在生物体内的功能：

通过抑制NOS的活性，科学家旨在阐明NOS在生物体内的具体功能，包括其在信号传导、免疫调节、血管舒张等方面的作用。

2. 探索心脑血管疾病的发病机制：

利用L-NAME hydrochloride诱导的高血压等心脑血管疾病模型，科学家可以深入研究这些疾病的发病机制，为开发新的治疗方法和预防策略提供理论基础。

3. 优化药物治疗方案：

通过研究L-NAME hydrochloride与其他药物的相互作用以及药效学特性，科学家可以优化药物治疗方案，提高药物治疗的针对性和有效性。

综上所述，L-NAME hydrochloride在科研领域中的研究方向广泛且深入，旨在阐明NOS在生物体内的功能、探索心脑血管疾病的发病机制以及优化药物治疗方案等。这些研究对于推动生物学、药理学以及医学领域的发展具有重要意义。

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